Seeking a highly motivated research scientist to join a dynamic core team within AbbVie’s Discovery Research function.
Within the Biotherapeutic Discovery Production group, contribute to protein analytics, engineering, and production in support of biologics drug discovery.
A key area of focus for this position will be in-depth analysis of Discovery biotherapeutic molecules by protein and peptide mass spectrometry, with the aim of fully characterizing the different candidates so as to advance the one(s) with the greatest probability of success.
The candidate must have diverse therapeutic protein expertise and an understanding of how to analyze post-translational modifications and disulfide bond structure of biologic molecules.
The candidate should be a creative problem-solver capable of finding innovative solutions to challenges posed in developing next-generation novel biotherapeutics.
This position will be based at our headquarters in North Chicago, IL.
Key Responsibilities:
Maintain a high level of productivity in the lab, conducting research independently and managing several projects simultaneously.
Autonomously design, execute, and interpret experimental results.
Contribute to project teams and work effectively across functional groups to help advance programs.
Stay current with applicable internal/external scientific literature and apply new information in innovative ways to successfully complete work assignments.
Routinely demonstrate scientific initiative and creativity in research activities.
Demonstrates high proficiency across a wide range of relevant technologies.
Analyze, document, and report data concisely and rigorously.
Qualifications:
BS or MS in Biochemistry, Biophysics, Chemical Engineering, or related field required.
Typically 1-3 years of relevant experience (with BS) or 0-1 years of relevant experience (with MS)
Demonstrated skill in identification and mapping of liabilities/PTMs in Biologic Drug Candidate molecules is a must.
Must be proficient in mass spec analysis of novel BiSpecific Biotherapeutics, especially as relates to correct disulfide structure and pairing of chains.
Practical experience and strong knowledge of protein and peptide HPLC techniques and theory, especially as applied to protein characterization.
Ability to deliver near “real-time” analytical results in order to guide the biotherapeutic candidate production process path is required.
Deep understanding of Protein Metrics and Mass Hunter analysis software is required.
Demonstrated ability to oversee, maintain, and troubleshoot liquid chromatography and mass spectrometry instrumentation.
Position will be hired based on level of experience.
Associate Scientist I or Associate Scientist II
AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion.
It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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